Application Type
Patents
Application SubType
PCT
(10) Registration Number and Date
Status
Filed-Data Capture
(180) Expiration Date
(20) Filing Number and Date
PG P/2025/000004 2023.07.06
(40) Publication Number and Date
(86) PCT Filing Number and Date
(87) PCT Publication Number and Date
(85) National Entry Date
(30) Priority Details
(71/73) Applicant
(72) Inventor
(EN) HORTOBÁGYI, Irén : Külsõ Szilágyi út 114. 6/16 1048 BUDAPEST
(EN) KOVÁCS, Szabolcs : Virág utca 24. 8/45 1045 BUDAPEST
(EN) PÓTI, Judit : Kóczán út 10/B/1 2230 Gyömrõ
(EN) RONSIN, Gael : 15 Square des Haies Vives 67000 Strasbourg
(EN) SÁNTÁNÉ CSUTOR, Andrea : Szárnyas utca 22. C 1107 BUDAPEST
(74) Representative Name
(54) Title
(EN) INDUSTRIAL PROCESS FOR THE PREPARATION OF HEXANOIC ACID, 6-(NITROOXY)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ETHYLAMINO)-7-OXO-2-HEPTEN-1-YL]-3,5-DIHYDROXYCYCLOPENTYL]-1-(2-PHENYLETHYL)-2-PROPEN-1-YL ESTER AND HIGH PURE PRODUCT
(57) Abstract
(EN) The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]- 3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester Compound (I). In accordance with the present invention, a pharmaceutical grade Compound (I) can be efficiently prepared by a one-pot reactions preparation step that includes the esterification of the 15-OH bimatoprost by coupling bimatoprost phenyl-boronate with 6- (nitrooxy)hexanoic acid
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(58) Citations