A dynamic optimization method for acid-to-ore ratio in high-pressure leaching of laterite nickel ore, includes obtaining a feed ore composition, a pulp concentration, a pulp flow rate, a leaching temperature and a pulp duration time in an autoclave, and setting a target leaching rate of nickel; setting a flow rate of sulfuric acid; obtaining a hydrogen ion concentration in a solution; obtaining a theoretical leaching rate of nickel when a leaching time reaches the pulp duration time in the autoclave; comparing the theoretical leaching rate of nickel with the target leaching rate of nickel. The beneficial effect of this disclosure is: providing a high-pressure acid leaching mathematical model and an optimal acid-to-ore ratio calculation method, calculating the optimal acid-to-ore ratio by inputting a real-time feed ore component into the high-pressure acid leaching mathematical model, thus, a sulfuric acid addition flow of a high-pressure leaching link of the clay nickel ore can be dynamically adjusted according to the feed mineral component, and a high-pressure acid leaching process is always in a dynamic optimal state with the optimal acid-to-ore ratio.