Disclosed is a system and method for regulating aluminum precipitation during high-pressure acid leaching of laterite nickel ore, the system comprises an autoclave, a subsequent processing equipment, and a control device; the autoclave comprises a kettle body, a first feeding pipe, a second feeding pipe, and a discharge pipe, the subsequent processing equipment is connected to the discharge pipe and is used to process the reactants; the control device comprises a first valve, a second valve, a first pressure sensor, a second pressure sensor, an aluminum ion detection device, and a control unit. This disclosure can maintain the aluminum ion concentration in the leachate within an appropriate range, effectively reducing fluctuations in the production process, achieving stable production, and lowering production and maintenance costs.